Histamine intolerance, seasonal reactivity, and immune dysregulation often have the same root: a system that is not getting what it needs to regulate itself. Well and Wild addresses this at the source.

The formula is five wild bison organs, each chosen for what it specifically contributes to histamine metabolism and immune function. The anchor is bison kidney - one of the richest natural food sources of DAO (diamine oxidase), the primary enzyme responsible for breaking down excess histamine in the body. When DAO levels are insufficient, histamine accumulates and produces the familiar symptoms: sinus congestion, skin irritation, headaches, digestive discomfort, and systemic inflammation. Bison kidney provides both the DAO enzyme and the essential cofactors required for effective histamine metabolism, supporting the body's own capacity to regulate histamine rather than simply suppressing its effects.

Bison liver brings its exceptional density of bioavailable nutrients to the immune and detoxification picture: Vitamin A for mucosal barrier integrity and immune signaling, the full B vitamin spectrum (including B12, folate, and riboflavin) for healthy methylation pathways critical to histamine processing, heme iron for oxygen transport and immune resilience, choline for liver detoxification and neurological function, and unique bioactive compounds including ergothioneine and LEAP-2 that support cellular protection and immune defense.

Bison thymus is one of the most targeted immune foods available. The thymus produces and educates T-lymphocytes - the cells that allow the immune system to recognize and respond to specific threats. It contains thymic peptides that support T-cell development and immune communication, helping to balance immune response rather than simply stimulate it. This balancing quality is particularly valuable for those experiencing histamine sensitivity, immune fatigue, or seasonal reactivity, where the goal is regulation rather than activation.

Bison pancreas delivers digestive enzymes that support the breakdown and absorption of nutrients - reducing the immune-triggering stress that poorly digested food places on the gut, and with it, the histamine and inflammatory burden that follows. Bison spleen contributes heme iron, alkylglycerols (AKGs), and the B vitamins and zinc that support immune signaling, tissue repair, and inflammatory balance.

Five organs. One formula. 3000mg per serving, freeze dried raw. 180 capsules, 30 servings.

Benefits: 

• Wild bison kidney - natural source of DAO enzyme and cofactors for histamine metabolism; supports detoxification and fluid balance
• Wild bison liver - bioavailable Vitamin A, B vitamins, heme iron, choline, ergothioneine, and LEAP-2 for immune resilience, methylation, and detoxification
• Wild bison thymus - thymic peptides that support T-cell development and immune balance; particularly valuable for histamine sensitivity and immune regulation
• Wild bison pancreas - digestive enzymes that reduce gut-based immune stress; contains T cells and B cells for immune tolerance
• Wild bison spleen - heme iron, alkylglycerols (AKGs), B vitamins, vitamin C, and zinc for immune strength and inflammatory balance
• Supports the body's natural ability to break down and regulate excess histamine
• Supports immune balance - helps regulate the immune response rather than simply stimulate it
• Supports mucosal barrier integrity - the body's first line of immune defense
• Supports healthy methylation pathways essential for histamine processing and detoxification
• Supports the gut-immune axis - reducing digestive triggers of immune reactivity
• 3000mg whole food organ blend per serving - freeze dried raw to preserve full biological integrity
• Prairie grass-fed and finished, Regenerative Organic Certified, humanely field harvested bison
• No synthetic antihistamines, isolated vitamins, fillers, or additives
• Made in USA. 180 capsules, 30-day supply.

How to Use: 

Take 6 capsules daily. Take all at once or divide into smaller doses throughout the day.

Take with food for best absorption.

For histamine support, consistency over time is key - give at least 90 days to assess the full cumulative benefit as DAO levels build.

If you are pregnant, breastfeeding, or taking medications, consult your healthcare provider before use.